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Disseminated intravascular coagulation (DIC) Health Article
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| Table of Contents |
Definition
Disseminated intravascular coagulation (DIC) is a serious disorder in which the proteins that control blood clotting are abnormally active.
Alternative Names
Causes, incidence, and risk factors
Normally, when you are injured, certain proteins are turned on and travel to the injury site to help stop bleeding. However, in persons with DIC, these proteins are abnormally active. Small blood clots form throughout the body. Overtime, the clotting proteins become "used up" and are unavailable during times of real injury. This disorder can result in clots or, more often, bleeding. Bleeding can be severe. Risk factors for DIC include:
Symptoms
Signs and tests
Treatment
The goal is to determine and treat the underlying cause of DIC. Blood clotting factors will be replaced with plasma transfusions. Heparin, a medication used to prevent thrombosis, is sometimes used in combination with replacement therapy.
Expectations (prognosis)
The underlying disease that causes the disorder will usually predict the probable outcome.
Complications
Calling your health care provider
Go to the emergency room or call 911 if you have continued bleeding of unknown cause.
Prevention
Get prompt treatment for conditions known to bring on this disorder.
References
Levi M. Disseminated intravascular coagulation: What's new? Crit Care Clin. Jul 2005; 21(3): 449-67. DeLoughery TG. Critical care clotting catastrophies. Crit Care Clin. Jul 2005; 21(3): 531-62. Gando S. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med. Mar 2006; 34(3): 625-31. |
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