Goodpasture syndrome Health Article

Definition

Goodpasture syndrome is a rare disease that involves rapidly progressive kidney failure along with lung disease.

However, some forms of the disease involve just the lung or kidney, not both.

Alternative Names

Anti-glomerular basement membrane antibody disease; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Pulmonary renal syndrome; Glomerulonephritis - pulmonary hemorrhage

Causes, incidence, and risk factors

Goodpasture syndrome is an autoimmune disorder, a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. Persons with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomureli) of the kidney.

These substances are called anti-glomerular basement membrane antibodies. Glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Anti-glomerular basement membrane are antibodies against this membrane. They can lead to kidney damage.

Sometimes the disorder is triggered by a viral respiratory infection or by breathing in hydrocarbon solvents. In such cases, the immune system may attack organs or tissues because it mistakes them for these viruses or foreign chemicals.

The immune system's faulty response causes bleeding in the air sacs and inflammation in the kidney's filtering units.

Men are eight times more likely to be affected than women. The disease most commonly occurs in early adulthood.

Symptoms

• Bloody urine
• Chest pain
• Cough with bloody sputum (coughing up blood)
• Dark colored urine
• Decreased urine output
• Difficulty breathing after activity
• Foamy urine
• Nausea and vomiting
• Pale skin
• Weakness

Signs and tests

A physical examination may reveal signs of high blood pressure and fluid overload. The health care provider may hear abnormal heart and lung sounds when listening to the chest with a stethoscope.

Urinalysis results are usually abnormal, and shows blood and protein in the urine. Abnormal red blood cells may be seen.

The following tests may also be done:

• Anti-glomerular basement membrane test
• Arterial blood gas
• BUN
• Chest x-ray
• Creatinine
• Lung biopsy
• Kidney biopsy