Liver metastases Health Article

Definition

Liver metastases is cancer that has spread to the liver from somewhere else in the body.

See also: Hepatocellular carcinoma

Alternative Names

Metastases to the liver

Causes, incidence, and risk factors

Cancers that may spread to the liver include:

• Breast cancer
• Colorectal cancer
• Esophageal cancer
• Lung cancer
• Melanoma
• Pancreatic cancer
• Stomach cancer

Cancer cells often have aggressive tendencies and will invade other areas of the body. They usually do this by floating in the bloodstream and then multiplying themselves in a new place.

Where and how cancer cells spread varies. It depends both on blood flow and on the characteristics of the different cancer cells. For example, cancers of the GI tract often spread to the liver because their blood drains directly through the liver. Melanoma usually spreads through the body's blood vessels to the liver.

The risk of cancer spreading to the liver depends on the site of the original cancer. The liver cancer may also be present when the original (primary) cancer is diagnosed, or it may occur months or years after the primary tumor is removed.

Symptoms

In some cases, there are no symptoms. When symptoms occur, they may include:

• Anorexia
• Fevers
• Jaundice
• Nausea
• Pain, usually in the upper right part of the abdomen
• Sweats
• Weight loss

Signs and tests

Tests that may be done to diagnose liver metastases include:

• Bilirubin blood test
• CT scan or MRI
• Liver function tests
• PET scan
• Ultrasound of the liver

Treatment

Treatment depends on:

• The primary cancer site
• How much of the cancer has spread to the liver (for example, only one tumor versus many tumors in the liver)
• Whether it has spread to other organs outside of the liver
• The patient's condition

When the cancer has spread to the liver and other organs, whole-body (systemic) chemotherapy is usually used.

When the spread is limited to the liver, systemic chemotherapy may still be used. However, other treatment methods may be effective. When the tumor is only in a few areas of the liver, the cancer may be removed with surgery.

The use of radiofrequency waves or injection of toxic substances may also be used to kill tumors. When larger areas of the liver are involved, treatment may involve chemotherapy directly into the liver, or a procedure to block blood flow to parts of the liver (embolization) to "starve" the tumor cells.