Oral sulfonylureas (like glimepiride, glyburide, and tolazamide) trigger the pancreas to make more insulin. Update Date: 06/17/2008Elizabeth H. Holt, MD, PhD, Assistant Professor of Medicine, Section of Endocrinology and Metabolism, Yale University. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.