Macroglossia is a congenital disorder where the tongue is larger than normal. It is enlarged because of an increase in the amount of tissue, not because of a tumor or growth. There is also a perceived macroglossia in Down syndrome possibly because the tongue frequently protrudes. Update Date: 11/12/2007Rachel A. Lewis, M.D., F.A.A.P., Columbia University Pediatric Family Practice, New York, NY. Review provided by VeriMed Healthcare Network.