Kidney Failure Health Channel

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Chronic kidney disease

Definition

Chronic kidney disease is the slow loss of kidney function over time. The main function of the kidneys is to remove wastes and excess water from the body.

Alternative Names

Kidney failure - chronic; Renal failure - chronic; Chronic renal insufficiency; Chronic kidney failure; Chronic renal failure

Causes, incidence, and risk factors

Chronic kidney disease (CKD) slowly gets worse over time. In the early stages, there may be no symptoms. The loss of function usually takes months or years to occur. It may be so slow that symptoms do not occur until kidney function is less than one-tenth of normal.

The final stage of chronic kidney disease is called end-stage renal disease (ESRD). The kidneys no longer function and the patient needs dialysis or a kidney transplant.

Chronic kidney disease and ESRD affect more than 2 out of every 1,000 people in the United States.

Diabetes and high blood pressure are the two most common causes and account for most cases.

Many other diseases and conditions can damage the kidneys, including:

Chronic kidney disease leads to a buildup of fluid and waste products in the body. This condition affects most body systems and functions, including red blood cell production, blood pressure control, and vitamin D and bone health.

Symptoms

The early symptoms of chronic kidney disease often occur with other illnesses, as well. These symptoms may be the only signs of kidney disease until the condition is more advanced.

Symptoms may include:

  • General ill feeling and fatigue
  • Generalized itching (pruritus) and dry skin
  • Headaches
  • Weight loss without trying to lose weight
  • Appetite loss
  • Nausea

Other symptoms that may develop, especially when kidney function has worsened:

  • Abnormally dark or light skin
  • Bone pain
  • Brain and nervous system symptoms
    • Drowsiness and confusion
    • Problems concentrating or thinking
    • Numbness in the hands, feet, or other areas
    • Muscle twitching or cramps
  • Breath odor
  • Easy bruising, bleeding, or blood in the stool
  • Excessive thirst
  • Frequent hiccups
  • Low level of sexual interest and impotence
  • Menstrual periods stop (amenorrhea)
  • ...

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Acute kidney failure (1 image) (Doctor-Reviewed information)
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Peritonitis - dialysis associated (1 image) (Doctor-Reviewed information)
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End-stage kidney disease (1 image) (Doctor-Reviewed information)
End-stage kidney disease is the complete, or almost complete failure of the kidneys to function. The kidneys can no longer remove wastes, concentrate urine, and regulate many other important body functions.Reviewer: Parul Patel, MD, Private practice specializing in Nephrology, Kidney and Pancreas Transplantation, affiliated with California Pacific Medical Center Department of Transplantation, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 08/12/2009

Renovascular hypertension (1 image) (Doctor-Reviewed information)
Renovascular hypertension is high blood pressure due to narrowing of the arteries that carry blood to the kidneys. See also: Atheroembolic renal disease; Hypertension; Malignant hypertension.Reviewer: Parul Patel, MD, Private Practice specializing in Nephrology and Kidney and Pancreas Transplantation, Affiliated with California Pacific Medical Center, Department of Transplantation, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 05/20/2009

Chronic bilateral obstructive uropathy (2 images) (Doctor-Reviewed information)
Chronic bilateral obstructive uropathy is a long-term blockage of urine flow from both kidneys. It is a slow blockage that gets worse over time. Bilateral means "both sides." See also: Chronic unilateral obstructive uropathy; Acute unilateral obst...Reviewer: Marc A. Greenstein, D.O., F.A.C.O.S. Urologist, Somerset Medical Center in Somerville, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 01/24/2008

Prerenal azotemia (2 images) (Doctor-Reviewed information)
Prerenal azotemia is an abnormally high level of nitrogen-type wastes in the blood.Reviewer: Parul Patel, MD, Private Practice specializing in Nephrology and Kidney and Pancreas Transplantation, affiliated with California Pacific Medical Center, Department of Transplantation, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 08/12/2009

Renal and urological disorders (2 images) (Doctor-Reviewed information)
Renal disorders refers to any disease of the kidneys. Urological disorders are diseases of the kidneys/urinary tract. This includes: Kidneys, ureters, urinary bladder, and urethra; Male reproductive organs including the testes, epididymis, vas def...Reviewer: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 08/09/2009

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