Syphilis Health Channel

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Syphilis, secondary on the palms

Late-stage syphilis

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Syphilis

Definition

Syphilis is infection with the bacteria Treponema pallidum.

Alternative Names

Lues; Cupid's disease; Syph

Causes, incidence, and risk factors

Syphilis is a sexually-transmitted infectious disease. The bacteria that cause it spread through broken skin or mucous membranes.

Pregnant mothers infected with the disease can pass it to the baby developing in their womb. This is called congenital syphilis.

Syphilis is widespread in the United States. It mainly affects sexually active adults ages 20 to 29.

Syphilis has several stages.

  • Primary syphilis is the first stage. Painless sores ( chancres) form at the site of infection about 2-3 weeks after you are first infected. You may not notice the sores or any symptoms, particularly if the sores are inside the rectum or cervix. The sores disappear in about 4-6 weeks, even without treatment. The bacteria become dormant (inactive) in your system at this stage. For more specific information about this type of syphilis, see primary syphilis.
  • Secondary syphilis occurs about 2-8 weeks after the first sores form.

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Syphilis - primary (2 images) (Doctor-Reviewed information)
Syphilis is a frequently diagnosed sexually transmitted disease.Reviewer: Linda Vorvick, MD, Seattle Site Coordinator, Maternal & Child Health Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; Susan Storck, MD, FACOG, Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine; Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 08/01/2008

Syphilis - secondary (1 image) (Doctor-Reviewed information)
Secondary syphilis is the second stage of the sexually transmitted disease syphilis. This stage is the most contagious.Reviewer: Linda Vorvick, MD, Seattle Site Coordinator, Maternal & Child Health Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; Susan Storck, MD, FACOG, Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine; Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 08/01/2008

Syphilis - tertiary (2 images) (Doctor-Reviewed information)
Tertiary syphilis is a late phase of the sexually transmitted disease syphilis, caused by the spirochete Treponema pallidum.Reviewer: Linda Vorvick, MD, Seattle Site Coordinator, Maternal & Child Health Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; Susan Storck, MD, FACOG, Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine; Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 08/01/2008

Genital sores - male (Doctor-Reviewed information)
A male genital sore is any sore or lesion that appears on the penis, scrotum, or male urethra.Reviewer: Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; and Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc. Date: 07/27/2009

Genital sores - female (1 image) (Doctor-Reviewed information)
Sores or lesions on the female genitalia or in the vagina may have a number of possible causes.Reviewer: Daniel N. Sacks, MD, FACOG, Obstetrics & Gynecology in Private Practice, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by Linda Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine; and David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc. Date: 12/14/2009

Congenital syphilis (Doctor-Reviewed information)
Congenital syphilis is a severe, disabling, and often life-threatening infection seen in infants. A pregnant mother who has syphilis can spread the disease through the placenta to the unborn infant.Reviewer: Linda J. Vorvick, MD, Medical Director, MEDEX Norhtwest Division of Physician Assistant Studies, University of Washington School of Medicine; and Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.Date: 11/02/2009

VDRL test (1 image) (Doctor-Reviewed information)
The VDRL test is a screening test for syphilis. It measures substances, called antibodies, that can be produced in response to Treponema pallidum, the bacteria that causes syphilis. The test is similar to the newer rapid plasma reagin (RPR) test.Reviewer: A.D.A.M. Editorial Team: David Zieve, MD, MHA, Greg Juhn, MTPW, David R. Eltz. Previously reviewed by Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington, School of Medicine; Susan Storck, MD, FACOG, Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, Washington; Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine (7/29/2009). Date: 12/02/2009

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