Amyotrophic Lateral Sclerosis Health Article

Signs and symptoms

The disease starts slowly, affecting just one limb, such as the hands or feet, and steadily progresses to more limbs and muscles. When muscles lack the proper nourishment they require, they begin to thin and deteriorate. This condition is the hallmark of amyotrophic lateral sclerosis. Muscle wasting is due to the inability of degenerating motor neurons to elicit a signal to the muscles that allow them to function and grow. Common examples of symptoms for ALS are muscle cramps and twitching, weakness in the hands, feet, or ankles, speech slurring, and swallowing difficulties. Other early symptoms include arm and leg stiffness, foot drop, weight loss, fatigue, and difficulty making facial expressions.

One of the earliest symptoms of ALS is weakness in the bulbar muscles. These muscles in the mouth and throat assist in chewing, swallowing, and speaking. Weakness of these muscle groups usually cause problems such as slurred speech, difficulty with conversation and hoarseness of the voice.

Another symptom of ALS that usually occurs after initial symptoms appear is persistent muscle twitching (fasciculation). Fasciculation is almost never the first sign of ALS.

As the disease progresses the respiratory muscles (breathing muscles) weaken, resulting in increased difficulty with breathing, coughing and possibly inhaling food or saliva. The potential for lung infection increases and can cause death. Many patients find it more comfortable and extend their lives when assisted by ventilators at this stage of the disease. Communication becomes very difficult. One way to accomplish feedback with others is to make use of the eyes. Blinking is one mode that patients of amyotrophic lateral sclerosis will be forced to utilize, in order to continue communication.

As the disease progresses, victims gradually lose the use of their feet, hand, leg, and neck muscles, and paralysis results in affected muscle groups. They are able to speak and swallow only with great struggle. Sexual dys-function is not affected. Breathing will become increasingly difficult and the patients of ALS may decide to prolong life with the use of assisted ventilation, which may decrease the risks of death from infections such as pneumonia.

Diagnosis

ALS is difficult to diagnose. There is no one set way to test for the disease. A series of diagnostic tests will

rule out and exclude other possible causes and diseases that resemble ALS. Electro diagnostic tests such as electromyography (EMG) and nerve conduction velocity (NCV) are used to help diagnose ALS. Blood and urine tests, spinal taps, x rays, and muscle and/or nerve biopsy are performed, as well as magnetic resonance imaging (MRI), myelograms of the cervical spine and a complete neurological exam.

A second opinion is frequently recommended if ALS is suspected since it is a fatal neurological disease. After a complete medical exam and family history check has been administered, other tests such as a CT (computed tomography) scan may be done to continue ruling out other causes. Many symptoms mimic ALS such as tumors of the skull base or upper cervical spinal cord, spinal arthritis, thyroid disease, lead poisoning, and severe vitamin deficiency. Other possibilities to rule out are multiple sclerosis, spinal cord neoplasm, polyarteritis, syringomyelia, myasthenia gravis, and muscular dystrophy. Amyotrophic lateral sclerosis is hardly ever misdiagnosed after this intensive series of diagnostic tests.

Treatment and management

Currently, there is no treatment for ALS. Management aims to control the symptoms that patients

experience. Emotional, psychological and physical support, are provided to ease the difficulty associated with this disorder.

Moderate activities are recommended in the early stages of the disease. Physical therapy can help muscles stay active and delay the resulting weakness. ALS patients are encouraged to maintain a healthy diet and exercise regularly for as long as possible. Education of ALS is very important in developing an understanding of the disease, and is vital for family members as well as patients.

Although there are no set treatments for ALS there are still many special considerations that can assist in the quality of lifestyle for the patient. Implementing a physical therapy program, providing a wheelchair or walker, assistance when bathing, and suction machines to help evacuate accumulated secretions all help the ALS patient. Other considerations include providing foods that are soft and easy to swallow, skin maintenance, feeding tubes, ventilation maintenance and emotional support.

Researchers have developed a drug approved by the Food and Drug Administration (FDA) called Rilutek (riluzole). The drug was the first to have a positive effect in that it appears to extend the life of ALS patients by about three months.

Another drug, Myotrophin (somatomedin C), appears to prevent neuron loss and enhance neuron generation in animal studies.