Open Prostatectomy Health Article

Definition

Open prostatectomy is a procedure for removal of an enlarged prostate gland.

Purpose

The primary indication for open prostatectomy is benign prostatic hyperplasia (BPH), a condition whereby benign or noncancerous nodules grow in the prostate gland. The prostate gland is composed of smooth muscle cells, glandular cells, and cells that give the gland structure (stromal cells). A dense fibrous capsule surrounds the prostate gland. The glandular cells produce a milky fluid that mixes with seminal fluid and sperm to make semen. The prostate gland also produces a hormone (dihydrotestosterone) that has a major impact on the gland's development.

Description

Open prostatectomy can be performed by either the retropubic or suprapubic approach. The preferred anesthesia for open prostatectomy is a spinal or epidural nerve block. Regional anesthesia can help reduce blood loss during surgery, and lowers the risk of complications such as pulmonary embolus and postoperative deep vein thrombosis. General anesthesia may be used if the patient has an anatomic or medical contraindication for regional anesthesia.

Demographics

The cause of BPH is not entirely known; however, the incidence increases with advancing age. Before 40 years of age, approximately 10% of males have BPH. A small amount of hyperplasia is present in 80% of males over 40 years old. Approximately 8–31% of males experience moderate to severe lower urinary tract symptoms (LUTS) in their fifties. By age 80, about 80% of men have LUTS. A risk factor is the presence of normally functioning testicles; research indicates that castration can minimize prostatic enlargement. It appears that the glandular tissues that multiply abnormally use male hormones produced in the testicles differently than the normal tissues do.

Approximately 5.5 million American males have BPH. It is more prevalent in the United States and Europe, and less common among Asians. BPH is more common in men who are married rather than single, and there is a strong genetic correlation. A man's chance for developing BPH is greater if three of more family members have the condition.