Conjugated Estrogens, Medroxyprogesterone Ac... Health Article

Generic name(s):

Conjugated Estrogens, Medroxyprogesterone Acetate Oral tablet

Brand name(s):

Premphase, Prempro

What is this medicine?

CONJUGATED ESTROGENS; MEDROXYPROGESTERONE (CON ju gate ed ESS troe jenz; me DROX ee proe JES te rone) is used as hormone replacement in menopausal women who still have their uterus. This medicine helps to treat hot flashes and prevent osteoporosis (weak bones).


This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• blood vessel disease or blood clots
• breast, cervical, endometrial, or uterine cancer
• diabetes
• endometriosis
• fibroids
• gallbladder disease
• heart disease or recent heart attack
• high blood cholesterol
• high blood pressure
• high level of calcium in the blood
• hysterectomy
• kidney disease
• liver disease
• mental depression
• migraine headaches
• porphyria
• stroke
• systemic lupus erythematosus (SLE)
• tobacco smoker
• vaginal bleeding
• an unusual or allergic reaction to estrogens, progestiins, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a drink of water. You may take this medicine with food. Follow the directions on the prescription label. You will take one tablet daily at roughly the same time each day. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient information sheet will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

• barbiturates, such as phenobarbital
• benzodiazepines
• bosentan
• bromocriptine
• carbamazepine
• cimetidine
• cyclosporine
• dantrolene
• grapefruit juice
• griseofulvin
• hydrocortisone, cortisone, or prednisolone
• isoniazid (INH)
• medications for diabetes
• methotrexate
• mineral oil
• phenytoin
• raloxifene
• rifabutin, rifampin, or rifapentine
• tamoxifen
• thyroid hormones
• topiramate
• tricyclic antidepressants
• warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.