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acetaminophen, diphenhydramine, and pseudoep... Health Article

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Doctor-reviewed Information, Multum Drug Directory, 2006
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What are the possible side effects of acetaminophen, diphenhydramine, and pseudoephedrine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
  • fast, pounding, or uneven heartbeat;

  • confusion, hallucinations, unusual thoughts or behavior;

  • severe dizziness, anxiety, restless feeling, or nervousness;

  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

  • urinating less than usual or not at all;

  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • blurred vision;

  • dry mouth;

  • mild loss of appetite;

  • nausea, stomach pain, constipation;

  • dizziness, drowsiness;

  • problems with memory or concentration;

  • ringing in your ears;

  • restless or excitability (especially in children);

  • sleep problems (insomnia);

  • skin rash, redness, or itching; or

  • warmth, tingling, or redness under your skin.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect acetaminophen, diphenhydramine, and pseudoephedrine?

Before taking this medication, tell your doctor if you are using any of the following drugs:

This list is not complete and there may be other drugs that can interact with acetaminophen, diphenhydramine, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen, diphenhydramine, and pseudoephedrine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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