What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include headache, nausea, vomiting, increased heart rate and fainting or dizziness (low blood pressure).

What should I avoid while using bosentan?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using bosentan.

What are the possible side effects of bosentan?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

nausea, stomach pain, loss of appetite;
dark urine, clay-colored stools; or
jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

headache;
flushing;
swelling of the feet, ankles, or legs;
dizziness;
upset stomach;
fatigue; or
itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect bosentan?

Do not take bosentan without first talking to your doctor if you are taking any of the following medicines:

an antifungal antibiotic such as ketoconazole (Nizoral), fluconazole (Diflucan), itraconazole (Sporanox), or voriconazole (Vfend);
tacrolimus (Prograf);
a blood thinner such as warfarin (Coumadin);
rifampin (Rifadin, Rifater, Rifamate, Rimactane);
ritonavir (Norvir); or
a cholesterol-lowering medicine such as simvastatin (Zocor), lovastatin (Mevacor), or atorvastatin (Lipitor).

This list is not complete and there may be other drugs not listed that can affect bosentan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about bosentan.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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