dolasetron Health Article

Generic name(s):

dolasetron

Brand name(s):

Anzemet

What is the most important information I should know about dolasetron?

Do not take dolasetron without first talking to your doctor if you have heart problems or if you take other medicines. Dolasetron can affect the way that your heart beats, which can be dangerous.

What is dolasetron?

Dolasetron blocks the actions of chemicals in the body that may cause nausea and vomiting.

Dolasetron is used to prevent nausea and vomiting associated with cancer chemotherapy or surgery.

Dolasetron may also be used for purposes other than those listed in this medication guide.

Who should not take dolasetron?

Do not take dolasetron without first talking to your doctor if you:

• have low levels of potassium in your blood;

• have low levels of magnesium in your blood;

• are taking a diuretic (water pill);

• have a history of congenital QT syndrome; or

• are taking a medicine to treat an irregular heartbeat.

Dolasetron may affect your heart, especially if you have any of the conditions or are taking any of the medicines listed above.

Dolasetron is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take dolasetron without first talking to your doctor if you are pregnant or if you are planning a pregnancy. It is not known whether dolasetron passes into breast milk. Do not take dolasetron without first talking to your doctor if you are breast-feeding a baby.

How should I take dolasetron?

Take dolasetron exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take the tablets with a full glass of water.

The injectable form of dolasetron is intended for intravenous use. However, it can also be used orally when mixed with apple or apple-grape juice as directed by your doctor. The mixture of dolasetron and juice is good for up to 2 hours at room temperature.

Dolasetron can be taken with or without food.

Store dolasetron at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a dolasetron overdose are not well known but might include tremors, seizures, and heart problems.

What should I avoid while taking dolasetron?

There are no restrictions on foods, beverages, or activities during treatment with dolasetron unless otherwise directed by your doctor.

What are the possible side effects of dolasetron?

If you experience any of the following uncommon but serious side effects, stop taking dolasetron and seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• irregular heartbeats; or

• muscle cramps or uncontrollable movements.

Other, less serious side effects may be more likely to occur. Continue to take dolasetron and talk to your doctor if you experience

• headache;

• fatigue, drowsiness, or dizziness; or

• diarrhea.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.