estradiol and levonorgestrel (topical patche... Health Article

Call your doctor at once if you have any of the following serious side effects:

• signs of a blood clot (sharp chest pain, coughing up blood, shortness of breath, pain in your calf);

• signs of a heart attack (crushing chest pain, left-arm numbness);

• signs of a stroke (sudden severe headache, problems with vision or speech, weakness, numbness);

• nausea, stomach pain, low fever, lost appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

• new or changing breast lumps.

Other less serious side effects are more likely to occur, such as:

• nausea and vomiting;

• tender or swollen breasts;

• swelling of the hands or feet;

• darkened spots on the skin of your face;

• contact lens discomfort;

• vaginal irritation or discomfort;

• headache, depressed mood;

• a skin rash or reaction where the patch is worn; or

• changes in your menstrual periods.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect estradiol and levonorgestrel?

Before using estradiol and levonorgestrel, tell your doctor if you are taking an anticoagulant (blood thinner) such as warfarin (Coumadin). You may not be able to use estradiol and levonorgestrel, or you may require a dosage adjustment or special tests during treatment.

There may be other drugs that can affect estradiol and levonorgestrel. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has additional information about estradiol and levonorgestrel written for health professionals that you may read.

What does my medication look like?

Estradiol and levonorgestrel is available with a prescription under the brand name Climara Pro as a topical skin patch (transdermal system). Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.