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glipizide and metformin Health Article

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Most Important What is...? Before Taking How to Take Missed Dose Avoid Taking Side Effects Interactions Overdose More Info
Doctor-reviewed Information, Multum Drug Directory, 2006
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Generic name(s):

glipizide and metformin

Brand name(s):

glipiZIDE-metformin, Metaglip

What is the most important information I should know about glipizide and metformin?

Do not use glipizide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking glipizide and metformin, tell your doctor if you have heart disease, liver disease, or a history of heart attack or stroke.

Some people have developed a life-threatening condition called lactic acidosis while taking glipizide and metformin. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking glipizide and metformin. Be sure the surgeon knows ahead of time that you are using this medication.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a source of sugar available in case you have symptoms of low blood sugar.

What is glipizide and metformin?

Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes.

Glipizide and metformin may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking glipizide and metformin?

Some people have developed a life-threatening condition called lactic acidosis while taking glipizide and metformin. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

You may be more likely to develop lactic acidosis if you have congestive heart failure.

Do not use glipizide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking this medication, tell your doctor if you have:

  • heart disease;

  • liver disease; or

  • a history of heart attack or stroke.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take glipizide and metformin.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether glipizide and metformin passes into breast milk or if it could harm a nursing baby. Do not take glipizide and metformin without first talking to your doctor if you are breast-feeding a baby. Older adults may have a higher risk of developing lactic acidosis. Talk with your doctor about your individual risk.
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