hydrochlorothiazide and irbesartan

Brand name(s):

hydrochlorothiazide-irbesartan, Avalide

What is the most important information I should know about irbesartan and hydrochlorothiazide?

You should not use this medication if you are allergic to irbesartan or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others), or if you are unable to urinate. Do not use this medication without telling your doctor if you are pregnant. Irbesartan and hydrochlorothiazide may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment. Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of irbesartan and hydrochlorothiazide.

What is irbesartan and hydrochlorothiazide?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Irbesartan is in a group of drugs called angiotensin II receptor antagonists. Irbesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

The combination of irbesartan and hydrochlorothiazide is used to treat high blood pressure (hypertension).

Irbesartan and hydrochlorothiazide may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking irbesartan and hydrochlorothiazide?

You should not use this medication if you are allergic to irbesartan or hydrochlorothiazide (Carozide, Diaqua, Ezide HCTZ, HydroDiuril, Microzide, and others), or if you are unable to urinate.

Before using irbesartan and hydrochlorothiazide, tell your doctor if you are allergic to any drugs, or if you have:

kidney disease;
liver disease;
congestive heart failure;
low or high levels of potassium in your blood;
asthma or allergies;
high cholesterol or triglyceride levels;
gout;
lupus;
diabetes; or
an allergy to sulfa drugs.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Irbesartan and hydrochlorothiazide may cause injury and even death to the unborn baby if you take it during the second and third trimesters of pregnancy. Do not use irbesartan and hydrochlorothiazide without your doctor's consent if you are pregnant. Use an effective form of birth control. Stop using this medication and tell your doctor right away if you become pregnant during treatment. It is not known whether irbesartan and hydrochlorothiazide passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

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