metoclopramide

Brand name(s):

Reglan

What is the most important information I should know about metoclopramide?

You should not take this medication if you are allergic to metoclopramide, or if you have bleeding or blockage in your stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).

Before taking metoclopramide, tell your doctor if you have kidney or liver disease, congestive heart failure, diabetes, or a history of depression.

Avoid drinking alcohol. It can increase some of the side effects of metoclopramide. There are many other medicines that can interact with metoclopramide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. Stop using metoclopramide and call your doctor at once if you have tremors or uncontrolled muscle movements, fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing, depressed mood, thoughts of suicide or hurting yourself, hallucinations, anxiety, agitation, seizure, or jaundice (yellowing of your skin or eyes). After you stop taking metoclopramide, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

What is metoclopramide?

Metoclopramide increases muscle contractions in upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Metoclopramide is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.

Metoclopramide is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can cause nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.

Metoclopramide may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking metoclopramide?

You should not take this medication if you are allergic to metoclopramide, or if you have:

bleeding or blockage in your stomach or intestines;
a perforation (hole) in your stomach or intestines;
epilepsy or other seizure disorder; or
an adrenal gland tumor (pheochromocytoma).

Before taking this medication, tell your doctor if you have

kidney disease;
liver disease (especially cirrhosis);
congestive heart failure;
diabetes (your insulin dose may need adjusting); or
a history of depression.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take metoclopramide.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Metoclopramide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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