What should I avoid while taking rifapentine?

Do not wear dentures or contact lenses while taking rifapentine. This medicine may discolor certain body fluids (including tears and saliva) with a red, orange, or brown color. While this is a harmless side effect, it may permanently stain a pair of contact lenses.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What are the possible side effects of rifapentine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

blood in your urine;
pale skin, weakness, easy bruising or bleeding; or
fever, chills, body aches, flu symptoms.

Less serious side effects may include:

red, orange, or brown discoloration of your skin, tears, sweat, saliva, urine, or stools;
nausea, vomiting, diarrhea, loss of appetite;
stomach pain;
headache;
joint pain; or
mild skin rash or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect rifapentine?

Before taking rifapentine, tell your doctor if you are using any of these HIV or AIDS medications:

There are many other medicines that can interact with rifapentine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about rifapentine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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