How should I take sulfasalazine oral?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medication after a meal. Do not crush, break, or chew a sulfasalazine tablet. Swallow the pill whole. The enteric-coated tablet has a special coating to protect your stomach. Breaking the pill could damage this coating. For best results, keep using the medication as directed. Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. If you are treating arthritis, do not stop using any of your other arthritis medications until your doctor tells you to. Your symptoms may not improve right away when you start taking sulfasalazine, and you may still need your other medications for awhile.

To be sure this medication is not causing harmful effects, your liver and kidney function may need to be checked with blood and urine tests on a regular basis. Do not miss any scheduled appointments.

Store sulfasalazine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, or seizure (convulsions).

What should I avoid while taking sulfasalazine oral?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using sulfasalazine.

What are the possible side effects of sulfasalazine oral?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sulfasalazine and call your doctor at once if you have any of these serious side effects:

fever, sore throat, or other flu symptoms;
pale skin, easy bruising;
dark urine, jaundice (yellowing of the skin or eyes);
pain or burning when you urinate;
urinating less than usual or not at all;
the appearance of a whole tablet in your stool; or
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

mild nausea, vomiting, diarrhea, upset stomach;
loss of appetite;
headache, ringing in your ears;
dizziness, spinning sensation;
white patches or sores inside your mouth or on your lips;
sleep problems (insomnia); or
mild itching or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect sulfasalazine oral?

Before taking sulfasalazine, tell your doctor if you are using any of the following drugs:

digoxin (digitalis, Lanoxin);
folic acid (Folicin, FA-8); or
vitamin or mineral supplements that contain folic acid.

This list is not complete and there may be other drugs that can interact with sulfasalazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about sulfasalazine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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