tipranavir

Brand name(s):

Aptivus

What is the most important information I should know about tipranavir?

Do not use this medication if you are allergic to tipranavir, or if you have moderate to severe liver disease. Do not take tipranavir with amiodarone (Cordarone, Pacerone), bepridil (Vascor), flecainide (Tambocor), propafenone (Rythmol), quinidine (Quinaglute, Quinidex), astemizole (Hismanal), terfenadine (Seldane), cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or an ergot medicine such as Ergomar, Cafergot, Wigraine, D.H.E. 45, Migranal, Methergine. These drugs can cause life-threatening side effects if you use them while you are taking tipranavir.

There are many other medicines that can interact with tipranavir.Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Tipranavir is used in combination with a similar drug called ritonavir (Norvir). Some people taking this combination of medicines have developed life-threatening medical problems including liver damage and bleeding in the brain. If you are taking these two medications, call your doctor at once if you have any of the following side effects:

unusual bleeding (such as a nosebleed or blood in your urine or stools);
sudden headache, confusion, problems with vision, speech, or balance;
low fever, nausea, stomach pain, loss of appetite;
dark urine, clay-colored stools; or
jaundice (yellowing of the skin or eyes).

What is tipranavir?

Tipranavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Tipranavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Tipranavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Tipranavir is not a cure for HIV or AIDS.

Tipranavir may also be used for purposes other than those listed in this medication guide.

What should I discuss with my health care provider before taking tipranavir?

Do not use this medication if you are allergic to tipranavir, if you have moderate to severe liver disease, or if you are using any of the following drugs:

amiodarone (Cordarone, Pacerone);
astemizole (Hismanal);
bepridil (Vascor);
cisapride (Propulsid);
flecainide (Tambocor);
midazolam (Versed) or triazolam (Halcion);
pimozide (Orap);
propafenone (Rythmol);
quinidine (Cardioquin, Quinidex, Quinaglute);
terfenadine (Seldane); or
or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

These drugs can cause life-threatening side effects if you use them while you are taking tipranavir.

Before taking tipranavir, tell your doctor if you are allergic to any drugs, or if you have:

liver disease (especially hepatitis B or C);
diabetes;
a bleeding disorder such as hemophilia; or
high chlolesterol or triglycerides.

If you have any of these conditions, you may not be able to use tipranavir, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. HIV can be passed to the baby if the mother is not properly treated during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Take all of your HIV medicines as directed to control your infection while you are pregnant.

Your name may need to be listed on an antiretroviral pregnancy registry when you start using this medication.

Tipranavir can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking tipranavir. You should not breast-feed while you are using tipranavir. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk.

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