vorinostat

Brand name(s):

Zolinza

What is the most important information I should know about vorinostat?

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Drink at least 2 liters of water each day to keep from getting dehydrated while you are taking vorinostat. Tell your doctor if you have severe vomiting or diarrhea during treatment.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not crush or open a vorinostat capsule. Swallow the pill whole. The medicine inside the capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If contact occurs, wash the skin area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of it.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. Do not miss any scheduled visits to your doctor.

What is vorinostat?

Vorinostat is used to treat skin problems caused by cutaneous T-cell lymphoma.

Vorinostat is usually given after other treatments have been tried without successful treatment of symptoms.

Vorinostat may also be used for purposes other than those listed in this medication guide.

What should I discuss with my health care provider before taking vorinostat?

Do not use this medication if you are allergic to vorinostat.

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:

diabetes;
liver disease;
kidney disease;
an electrolyte imbalance (such as high or low potassium levels);
a personal or family history of "Long QT syndrome";
a history of stroke or blood clot; or
if you have recently been vomiting or had diarrhea.

If you have any of these conditions, you may not be able to use vorinostat, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use vorinostat without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. It is not known whether vorinostat passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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